pentobarbital will decrease the level or outcome of colchicine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Intramuscular Administration: IM injection in the sodium salts of barbiturates ought to be designed deeply into a sizable muscle mass, in addition to a volume of 5 mL shouldn't be exceeded at Anybody web-site because of achievable tissue irritation.
Monoamine oxidase inhibitors (MAOI): MAOI lengthen the consequences of barbiturates possibly for the reason that metabolism on the barbiturate is inhibited.
pentobarbital will decrease the level or influence of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers may result in reduced serum concentrations and lack of antimalarial efficacy
pentobarbital will lessen the level or result of budesonide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the level or effect of nisoldipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will lessen the level or effect of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Sturdy or reasonable CYP3A4 inducers drastically minimize guanfacine plasma concentrations and elimination half-lifetime.
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pentobarbital will lower the level or impact of doxorubicin liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
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pentobarbital will lower the level or impact of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Pitolisant publicity is reduced by fifty% if coadministered with sturdy CYP3A4 inducers.
pentobarbital will reduce the extent or result of felodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lessen the extent or outcome of tipranavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
DESCRIPTION The barbiturates are nonselective central nervous process depressants that are principally employed read more as sedative hypnotics in addition to anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are issue to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section). The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are offered as sterile parenteral alternatives. Barbiturates are substituted pyrimidine derivatives during which The fundamental construction typical to these prescription drugs is barbituric acid, a substance that has no central nervous process (CNS) action.